Role of MAP kinase-dependent apoptotic pathway in innate immune responses and viral infection.
Identifieur interne : 002158 ( Main/Exploration ); précédent : 002157; suivant : 002159Role of MAP kinase-dependent apoptotic pathway in innate immune responses and viral infection.
Auteurs : V V Sumbayev [Ukraine] ; I M YasinskaSource :
- Scandinavian journal of immunology [ 0300-9475 ] ; 2006.
Descripteurs français
- KwdFr :
- Animaux, Apoptose (immunologie), Humains, Immunité innée, MAP Kinase Kinase 4 (physiologie), MAP Kinase Kinase Kinase 5 (physiologie), Maladies virales (anatomopathologie), Maladies virales (enzymologie), Maladies virales (immunologie), Transduction du signal (immunologie), p38 Mitogen-Activated Protein Kinases (physiologie).
- MESH :
- anatomopathologie : Maladies virales.
- enzymologie : Maladies virales.
- immunologie : Apoptose, Maladies virales, Transduction du signal.
- physiologie : MAP Kinase Kinase 4, MAP Kinase Kinase Kinase 5, p38 Mitogen-Activated Protein Kinases.
- Animaux, Humains, Immunité innée.
English descriptors
- KwdEn :
- Animals, Apoptosis (immunology), Humans, Immunity, Innate, MAP Kinase Kinase 4 (physiology), MAP Kinase Kinase Kinase 5 (physiology), Signal Transduction (immunology), Virus Diseases (enzymology), Virus Diseases (immunology), Virus Diseases (pathology), p38 Mitogen-Activated Protein Kinases (physiology).
- MESH :
- chemical , physiology : MAP Kinase Kinase 4, MAP Kinase Kinase Kinase 5, p38 Mitogen-Activated Protein Kinases.
- enzymology : Virus Diseases.
- immunology : Apoptosis, Signal Transduction, Virus Diseases.
- pathology : Virus Diseases.
- Animals, Humans, Immunity, Innate.
Abstract
Mitogen-activated protein (MAP) kinase cascades are multifunctional signalling networks that influence cell growth, differentiation, apoptosis and cellular responses to stress. Apoptosis signal-regulating kinase 1 (ASK1) is a MAP kinase kinase kinase that triggers apoptogenic kinase cascade leading to the phosphorylation/activation of c-Jun N-terminal kinases (JNK) and p38-MAP kinase, which are responsible to induce apoptotic cell death. This pathway plays a pivotal role in the transduction of signals from different apoptotic stimuli. Recently, it has become evident that ASK1 and its downstream pathway are employed in the transduction of signals from Toll-like receptors (TLR) - multistep processes that interfere with different intracellular signalling pathways. TLR are the key proteins that allow mammals to detect pathogens and mediate innate immune responses. In addition, ASK1 and its downstream pathway play a target role in the regulation of apoptosis in some cases of viral infection - AIDS, influenza, hepatitis C and others. In the present review, we summarize current knowledge about the role of ASK1 and its downstream pathway in innate immune responses and viral infection.
DOI: 10.1111/j.1365-3083.2006.001764.x
PubMed: 16764692
Affiliations:
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Le document en format XML
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immune responses and viral infection.</title><author><name sortKey="Sumbayev, V V" sort="Sumbayev, V V" uniqKey="Sumbayev V" first="V V" last="Sumbayev">V V Sumbayev</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Mechnikov Odessa National University, Odessa, Ukraine. sumbayev@yahoo.co.uk</nlm:affiliation><country xml:lang="fr">Ukraine</country><wicri:regionArea>Department of Biochemistry, Mechnikov Odessa National University, Odessa</wicri:regionArea><wicri:noRegion>Odessa</wicri:noRegion></affiliation></author><author><name sortKey="Yasinska, I M" sort="Yasinska, I M" uniqKey="Yasinska I" first="I M" last="Yasinska">I M Yasinska</name></author></analytic><series><title level="j">Scandinavian journal of immunology</title><idno type="ISSN">0300-9475</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Apoptosis (immunology)</term><term>Humans</term><term>Immunity, Innate</term><term>MAP Kinase Kinase 4 (physiology)</term><term>MAP Kinase Kinase Kinase 5 (physiology)</term><term>Signal Transduction (immunology)</term><term>Virus Diseases (enzymology)</term><term>Virus Diseases (immunology)</term><term>Virus Diseases (pathology)</term><term>p38 Mitogen-Activated Protein Kinases (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Apoptose (immunologie)</term><term>Humains</term><term>Immunité innée</term><term>MAP Kinase Kinase 4 (physiologie)</term><term>MAP Kinase Kinase Kinase 5 (physiologie)</term><term>Maladies virales (anatomopathologie)</term><term>Maladies virales (enzymologie)</term><term>Maladies virales (immunologie)</term><term>Transduction du signal (immunologie)</term><term>p38 Mitogen-Activated Protein Kinases (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>MAP Kinase Kinase 4</term><term>MAP Kinase Kinase Kinase 5</term><term>p38 Mitogen-Activated Protein Kinases</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Maladies virales</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Maladies virales</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Apoptose</term><term>Maladies virales</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Apoptosis</term><term>Signal Transduction</term><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Virus Diseases</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>MAP Kinase Kinase 4</term><term>MAP Kinase Kinase Kinase 5</term><term>p38 Mitogen-Activated Protein Kinases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Immunity, Innate</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Immunité innée</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mitogen-activated protein (MAP) kinase cascades are multifunctional signalling networks that influence cell growth, differentiation, apoptosis and cellular responses to stress. Apoptosis signal-regulating kinase 1 (ASK1) is a MAP kinase kinase kinase that triggers apoptogenic kinase cascade leading to the phosphorylation/activation of c-Jun N-terminal kinases (JNK) and p38-MAP kinase, which are responsible to induce apoptotic cell death. This pathway plays a pivotal role in the transduction of signals from different apoptotic stimuli. Recently, it has become evident that ASK1 and its downstream pathway are employed in the transduction of signals from Toll-like receptors (TLR) - multistep processes that interfere with different intracellular signalling pathways. TLR are the key proteins that allow mammals to detect pathogens and mediate innate immune responses. In addition, ASK1 and its downstream pathway play a target role in the regulation of apoptosis in some cases of viral infection - AIDS, influenza, hepatitis C and others. In the present review, we summarize current knowledge about the role of ASK1 and its downstream pathway in innate immune responses and viral infection.</div></front></TEI><affiliations><list><country><li>Ukraine</li></country></list><tree><noCountry><name sortKey="Yasinska, I M" sort="Yasinska, I M" uniqKey="Yasinska I" first="I M" last="Yasinska">I M Yasinska</name></noCountry><country name="Ukraine"><noRegion><name sortKey="Sumbayev, V V" sort="Sumbayev, V V" uniqKey="Sumbayev V" first="V V" last="Sumbayev">V V Sumbayev</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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